Disease Profile in the Archive: Pagets Disease - By: Ronald K. Redman

For severaly years, bisphosphonates like Fosamax stays as one of the most recommended medication in the United States. However, you can say that the drug and Merck, its manufacturer, also had their bad times when you look back and ahead at Fosamax lawsuits. This, and other drugs on the same classification are considered as the osteoporosis’ first line of treatment. Additionally, this drug is also prescribed to treat a less popular bone condition known as Paget’s disease.

More than 8.2 million people States have already been diagnosed with Paget’s disease, also known to many as osteitis deformans, making it the most prevalent bone disease in the United States after osteoporosis. Added to that, it rarely occurs in people younger than 40 years old and its ratio from male to female is 1.2:1. Although the disease can prevail in different areas in the world, it occurs predominantly in European countries such England, France and Germany.

Paget’s disease is a chronic disorder, usually contained in one location, that can result in enlarged and deformed bones. Initially in Paget’s disease, the bone remodeling cycle loses balance as bone resorption becomes faster due to the rising number of bone cells responsible for the bone breakdown. It is then followed by the phase with increased bone formation which later results in a weaker than normal adult bone.

Paget’s disease may involve any bone in the body though it seems to occur mostly on long bones, spine, skull, and the pelvis. Most of the time, people with continue to live without knowing that they have Paget’s disease chiefly because this disease is often asymptomatic. Nonetheless, other patients may manifest localized symptoms depending on the bone affected with the said disease.

When left untreated, this disease can lead to certain complications. Paget’s disease affecting the skull for instance, can lead to the following adverse conditions:

- Deafness

- Vertigo

- Tinnitus

- Dental malocclusion

- Basilar invagination

- Cranial nerve disorders

In most cases, people who are diagnosed with Paget’s disease are treated with Fosamax or other bisphosphonates. It has been found, however, that the use of Fosamax could potentially increase your risk of developing certain problems including low-impact thigh bone fractures. A significant number of people claiming to have been laid up by the long term effects of the drug are now determined to file a Fosamax lawsuit against Merck.

About the Author

Ronald, like many others, is concerned about a potential Fosamax lawsuit. Those affected by Fosamax medication can check here regularly for updates.

Article Directory Source: http://www.articlerich.com/profile/Ronald-K--Redman/172117

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